Abstract Background Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor neuron system associated with both genetic and environmental risk factors.Infection with enteroviruses, including poliovirus and coxsackievirus, such as coxsackievirus B3 (CVB3), has been proposed as a possible causal/risk factor for ALS due to
Eimeria species parasites can cause the enteric disease coccidiosis, most notably Cocoa Powder in chickens where the economic and welfare implications are significant.Seven Eimeria species are recognized to infect chickens, although understanding of their regional occurrence, abundance, and population structure remains limited.Reports of Eimeria ci
Abstract Background Computational identification of non-coding RNAs (ncRNAs) is a challenging problem.We describe a genome-wide analysis using Bayesian segmentation to identify intronic elements highly conserved between three evolutionarily distant vertebrate species: Time Release human, mouse and zebrafish.We investigate the extent to which these
The small ubiquitin-related modifier (SUMOylation) system is a conserved, reversible, post-translational protein modification pathway covalently attached to the lysine residues of proteins in eukaryotic cells, and SUMOylation is catalyzed by SUMO-specific activating enzyme (E1), binding enzyme (E2) and ligase (E3).Sentrin-specific proteases (SENPs)